Synthesis, Characterization and Single Crystal X-ray Diffraction Analysis of Fused Triazolo/Thiadiazole Clubbed with Indole Scaffold

The present synthetic strategy involves the synthesis of indolyl-triazolo-thiadiazole heterocyclic ring systems 8–13 from condensation 4-amino-5-(1H-indol-2-yl)-3H-1,2,4-triazole-3-thione 1 with aromatic carboxylic acid derivatives 2–7 in presence POCl3 for h. All compounds were obtained very good yields and have been well-characterized using spectroscopic techniques. Exclusively, quality crystals target organic hybrid 8-(1H-indol-2-yl)-5-(p-tolyl)-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazole 9 found suitable X-ray single crystal diffraction measurement, which is used to confirm analyze molecular supramolecular structure aspects 9. solid-state synthesized molecule agrees well other characterizations. packing dominated by N…H, S…H, C…C S…C non-covalent interactions, agree Hirshfeld surface analysis. percentages these contacts are calculated be 20.3%, 5.4%, 9.4% 4.3%, respectively.